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Recent reports have correlated multidrug resistance (MDR) and P-glycoprotein expression with decreased Fas expression and resistance to Fas-mediated apoptosis. We report the MRP-overexpressing MDR subline CEM/E1000 has the same Fas expression (MFI 74.3+/-0.7) as the parental CCRF-CEM T-cell leukaemia cells (MFI 70.0+/-3.6; P>0.05), and that the level of apoptosis induced by anti-Fas antibody or...
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