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Purpose
Muller glial cells (MGC) are involved in the retinal homeostasis and they are sustaining cholesterol homeostasis. A lack or an excess of cholesterol in neurons can cause neuro‐degeneration. Cholesterol is eliminated from the retina mainly as 24S‐hydroxycholesterol (24S‐OHC). 24S‐OHC is produced by 24S‐hydroxylase (CYP46A1) in retinal ganglion cells (RGC) and is overexpressed during glaucoma...
Purpose Gangliosides are glycosphingolipids particularly abundant in the brain and nervous system, including the retina. A large variety of gangliosides have been described and the profile is specific to the organ or cell type. It has been shown that ganglioside composition of the retina changes during development. Also, it is known that mouse models accumulating specific gangliosides exhibit retinal...
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