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Background
To date, lactate dehydrogenase (LDH) and S100B remain the most useful biomarkers for follow‐up of melanoma patients. In recent years, indoleamine 2,3‐dioxygenase (IDO), an immunosuppressive enzyme, has been proposed as a new potential tumour biomarker for melanoma. However, further studies are needed to confirm the usefulness of IDO expression as an independent prognostic factor.
Objective...
Objective To study the effects of proteolytic enzymes on mice hair follicles, particularly on cells of the bulge area regarded as follicle stem cells.Background Previous application by iontophoresis of proteolytic enzymes on guinea pig skin resulted in degenerative effects on hair follicles and the hypothesis was proposed that some of the affected cells could be stem cells.Methods To mark putative...
The proteolytic enzymes tryspin, chymotryspin and papain exert profound histological effects on guinea pig hair follicles. The application of the same enzymes to the skin of hirsutic women leads to permanent depilatory effects. We hypothesized that stem cells are among the follicle cells affected. To test this hypothesis, we evaluated the effects of the enzymes on hair follicles of transgenic mice...
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