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Isoquinoline derivatives exert 1-methyl-4-phenylpyridinium (MPP + )-like activity as inhibitors of complex I and α-ketoglutarate dehydrogenase activity in rat brain mitochondrial fragments. We now examine the ability of 19 isoquinoline derivatives and MPP + to accumulate and inhibit respiration in intact rat liver mitochondria, assessed using polarographic techniques. None of the...
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