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Fluvoxamine (FVX) is a clinically effective antidepressant that, because of its potent and specific inhibition of the serotonin (5-HT) reuptake, is regarded as a selective 5-HT reuptake inhibitor. Acutely administered, FVX increases extracellular brain concentrations of 5-HT but not of norepinephrine and binds with little or no affinity to adrenoreceptors ([alpha ] 1 -, [alpha ] 2 ...
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