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BackgroundPediatric neuroectodermal malignancies express N‐glycolylated gangliosides including N‐glycolyl GM3 (NeuGcGM3) as targets for immunotherapy.
ProcedureWe evaluated the toxicity and maximum tolerated dose and immunological response of racotumomab, an anti‐idiotype vaccine targeting NeuGcGM3 through a Phase I study enrolling children with relapsed or resistant tumors expressing NeuGcGM3.
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