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A variety of measures of neuropathology in Alzheimer's disease (AD) correlate with dementia severity. However, the role of β-amyloid protein and abnormally phosphorylated tau protein in the decline of specific cognitive abilities is unknown. ‘Constructional praxis’ (e.g. copying, constructing) is believed to require integrity of the parietal-occipital lobes. Unlike most other cognitive tasks, some...
Bcl-2 protein has been suggested to be one of the proteins preventing apoptosis in a variety of cell types. Recently, apoptosis has been suggested to have an important role in the pathogenesis of Alzheimer's disease (AD). We have utilized Bcl-2 immunohistochemical methods to examine Bcl-2 in the hippocampus and entorhinal cortex of AD patients ranging in clinical and neuropathological severity from...
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