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JONES, D. A., A. J. MacLELLAN, J. CUMMINGS, A. A. RITCHIE, S. P. LANGDON AND J. F. SMYTH. Processing of [d-arg 1 ,d-Phe 5 ,d-Trp 7,9 ,Leu 11 ]substance P in xenograft bearing Nu/Nu mice. PEPTIDES 18(7) 1073–1077, 1997.—[d-Arg 1 ,d-Phe 5 ,d-Trp 7,9 ,Leu 11 ]Substance P is a broad-spectrum neuropeptide growth factor antagonist that has...
H-Arg-d-Trp-N me Phe-d-Trp-Leu-Met-NH 2 (Antagonist G) will the first broad-spectrum neuropeptide antagonist to enter a phase I clinical trial. Its in vitro and in vivo metabolism has been extensively characterized. The major metabolites were identified and their structures elucidated by mass spectroscopy and amino acid analysis. Metabolism occurred almost exclusively at the C-terminus...
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