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Interferons (IFNs) augment the effect of some antitumor agents, including cis-diamminedichloroplatinum(II) (cDDP), in experimental systems. The effect of human recombinant interferon-alpha(2b) (rIFNα) on the cDDP-dependent growth delay in a human non-small cell lung cancer established as a xenograft in nude mice (NX002) has been investigated. IFN (10 5 IU/mouse, s.c.) as a single agent had...
[Arg 6 , D-Trp 7,9 , NmePhe 8 ]-substance P (6-11) (antagonist G) is a broad spectrum neuropeptide growth factor antagonist about to enter clinical trials as an anticancer drug. Its fate has been studied after incubation with two densities (5 10 4 cells/mL and 1 10 6 cells/mL) of the H69 small cell lung cancer cell line for up to 7 days at a...
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