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Ketamine has been used to model cognitive and behavioral symptoms of schizophrenia. Current hypotheses state that inadequate glutamatergic transmission in schizophrenia leads to a deficiency in γ-aminobutyric acid (GABA)ergic inhibitory mechanisms and treatment with a GABA type A receptor subunits α2/α3 (GABA Aα2/3 ) modulator improved working memory performance in a preliminary study in patients...
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