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We investigated the effectiveness of ketamine as a primary therapy for prehospital profound agitation.This was a prospective observational study of patients receiving 5mg/kg of intramuscular ketamine for profound agitation, defined as a score of +4 on the Altered Mental Status Scale (AMSS), a validated ordinal scale of agitation from −4 (unresponsive) to +4 (most agitated). The primary outcome was...
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