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We report here a case of diffuse Lewy body disease with the A53T mutation in the α-synuclein gene. The proband presented at the age of 41 years with parkinsonism that was poorly responsive to levodopa. She subsequently developed cognitive impairment and moderate dementia, and died at the age of 50. Her father, paternal grandfather and uncle were all reported to have suffered from Parkinson’s disease...
AbstractWe report a case of a 69-year-old woman with an 11-year history of progressive dementia, who was found at autopsy to have classic Picks disease pathology, as well as extensive paired helical filament immunoreactive neurities, with few Alzheimers disease (AD)-like neurofibrillary tangles and no senile plaques. Both Pick bodies and neuritic degeneration were extensive in the neocortex and hippocampal...
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