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Background
Non‐melanoma skin cancer (NMSC) and actinic keratosis (AK) are very common among fair‐skinned individuals. A disease continuum from AK to squamous cell carcinoma (SCC) has been frequently postulated. AK and NMSC may influence quality of life (QL) of patients, and it can be suspected that disease progression entails a QL reduction. The purpose of this study was to document QL in patients...
In order to establish an alternative to the Draize test, an in vitro skin irritancy test was developed with human keratinocyte-derived proinflammatory interleukin-1α and eicosanoids as in vitro parameters. These are currently validated for their relevance and reliability: In a clinical study the eicosanoid and the IL-1α content of human suction blister fluid (SBF) and skin inflammation (clinical symptoms,...
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