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The pA2 (or log K) values at the muscarinic cholinergic receptor of the guinea pig ileum for a series of 1,3-dioxolanes have been correlated with the hydrophobic constant π and π2. A correlation coefficient of 0.97 and standard deviation of 0.30 were obtained with 16 of the 18 compounds (P < 0.05). A series of 17 analogues of amino esters of α-methyl tropic acid and α-substituted phenyl acetic...
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