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Earlier identification of potentially efficacious treatments in early development trials requires on‐treatment response markers. We hypothesized that mean week 12 or 24 HBsAg decline could be a useful marker for subsequent off‐treatment sustained HBsAg clearance at the treatment arm level in HBV trials. We used individual patient data from the studies HBV 9901 (peginterferon [PEG‐IFN] versus PEG‐IFN+lamivudine...
Prognosis of hepatitis B (HBV)‐associated hepatocellular carcinoma (HCC) is poor due to high rates of HCC recurrence and progression of underlying liver disease. We studied whether serum hepatitis B core‐related antigen (HBcrAg) levels could predict HCC recurrence and outcome in HBV associated. Higher HBcrAg levels at HCC diagnosis were independently associated with reduced overall and recurrence‐free...
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