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A composition and preparation method for new analgesic rectal suppositories containing a nonsteroidal anti-inflammatory drug (ketorolac), tricyclic antidepressant (amitriptyline), and transmucosal conductor (silicon glycerolates) as the active ingredients in a poly(ethylene glycol) (PEG-4000) base were proposed. The acute toxicity was determined and showed they were safe to use. The high analgesic...
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