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BACKGROUND
Daratumumab (DARA) is a human IgG1κ monoclonal antibody directed against CD38, approved for the treatment of multiple myeloma. As CD38 is expressed on RBCs, DARA can interfere with pretransfusion testing. DARA interference can be negated by denaturation of CD38 on RBCs with dithiothreitol (DTT) reagents. Because of this interference in pretransfusion testing, our hospital implemented a...
BACKGROUND
AABB requires that red blood cells (RBCs) are maintained at 1 to 10°C during transport. Historically, blood banks used the 30‐minute rule for returned RBCs transported outside of validated containers. The implications of this policy have not been previously reported in a real‐life hospital setting.
STUDY DESIGN AND METHODS
A 2‐year, retrospective review of RBC units returned outside...