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Radon and its progeny have been classified as human class I carcinogens by the IARC. However, the mechanisms by which radon induces lung and other cancers, especially the radon‐induced Warburg effect, have not been fully elucidated. The aim of this study was to investigate the role of the succinate dehydrogenase subunit A (SDHA)‐mediated Warburg effect in (human bronchial epithelial) BEAS‐2B cells...
Human small airway epithelial cells (SAECs) immortalized with human telomerase reverse transcriptase were exposed to either a single or multiple doses of α‐particles. Irradiated cells showed a dose‐dependent cytotoxicity and progressive neoplastic transformation phenotype. These included an increase in saturation density of growth, a greater resistance to N‐phosphonoacetyl‐L‐aspartate, faster anchorage‐independent...
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