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Follicular T‐cell lymphoma (FTCL) is considered to originate from follicular helper T‐cell (Tfh) cells. Angioimmunoblastic T‐cell lymphoma (AITL) and peripheral T‐cell lymphomas with the Tfh phenotype, derived from Tfh cells, often harbor RHOA G17V mutation. We investigated whether RHOA mutations affect the clinicopathological features of FTCL. We performed deep sequencing and Sanger sequencing for...
Janus Kinase 3 (JAK3) is a non‐receptor tyrosine kinase, predominantly expressed in hematopoietic cells, that plays an essential role in hematopoiesis during T cell development. JAK3 somatic‐activating mutations were identified in extranodal natural killer/T cell lymphomas (ENKTL) in recent cases in Singapore. We hypothesized these mutations might play an important role in the pathogenesis of T and...
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