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The underlying mechanism by which MyD88 regulates the development of obesity, metainflammation, and insulin resistance (IR) remains unknown. Global deletion of MyD88 in high-fat diet (HFD)-fed mice resulted in increased weight gain, impaired glucose homeostasis, elevated Dectin-1 expression in adipose tissue (AT), and proinflammatory CD11c+ AT macrophages (ATMs). Dectin-1 KO mice were protected from...
To investigate adrenal steroid regulation in polycystic ovary syndrome.Five-hour oral glucose tolerance test (OGTT) and frequently sampled-intravenous gluclose tolerance test.University research center.Thirty patients.None.Anthropometrics, leptin, cortisol, DHEAS, glucose, insulin.Morning cortisol correlated with sensitivity index (SI, r = .540), DHEAS correlated inversely with age (r = −.6359), body...
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