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Low testosterone is associated with late‐onset hypogonadism (LOH) and obesity. Recently, studies have shown that four single nucleotide polymorphisms (SNPs), rs12150660, rs727428, rs5934505, and rs10822184, are associated with testosterone levels in populations of European descent. Therefore, we investigated whether the SNP loci are related to low testosterone, LOH, or obesity in a Chinese Han population...
Summary. Single nucleotide polymorphisms (SNPs) near the IL28B gene have been shown to be associated with response to treatment for chronic hepatitis C and also with spontaneous clearance of hepatitis C virus (HCV) infection. We analysed the association between IL28B genetic variants and spontaneous clearance of HCV infection in 376 HCV‐infected Chinese paid plasma donors. Genotyping of eight SNPs...
Summary. Antiviral therapy is a potentially successful approach for the treatment of patients with Hepatitis B virus (HBV) infection. One antiviral agent is the nucleoside analogue adefovir dipivoxil (ADV). Its efficiency is compromised by the emergence of drug‐resistant HBV mutants. Although three major ADV‐resistant mutations of HBV are known, rtA181T/V and rtN236T, HBV mutations associated with...
Considering the flexibility of porous bearings, this paper applies the Brinkman model (BM) to study the influences of viscous shear stresses on the lubrication performance of long, flexible, porous journal bearings. It is found that the viscous shear effects of the BM signify an improvement in the steady characteristics of the system. A comparison with the Darcy model (DM) shows that the viscous shear...
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