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Summary
Background
Previous ex vivo studies using truncated VWF (von Willebrand factor) suggest that domain‐level molecular architecture may control platelet‐GpIbα binding function.
Objective
We determined if this is the case with multimeric VWF in vivo.
Methods
Full‐length human VWF (‘hV’) was modified with a 22‐amino acid mucinous stretch at either the N‐terminus of VWF‐A1 to create ‘hNV’...