Search results for: Mohammed M. Idris

Items from 1 to 10 out of 10 results

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Quantitative proteomic analysis of normal and degenerated human intervertebral disc

Nukala Sarath Babu, Sivaraman Krishnan, Cherukuvada V. Brahmendra Swamy, Goli P. Venkata Subbaiah, more

The Spine Journal > 2016 > 16 > 8 > 989-1000

Degenerative disc disease (DDD) is the most common disease of aging in humans. DDD is characterized by the gradual damage of the intervertebral discs. The disease is characterized by progressive dehydration of nucleus pulposus and disruption of annulus fibrosus of intervertebral disc.Even though it is highly prevalent, there is no effective therapy to regenerate the degenerated disc, or decrease or...

article

Role of annexin gene and its regulation during zebrafish caudal fin regeneration

Sandeep Saxena, Sruthi Purushothaman, Vuppalapaty Meghah, Bhawna Bhatti, more

Wound Repair and Regeneration > 24 > 3 > 551 - 559

The molecular mechanism of epimorphic regeneration is elusive due to its complexity and limitation in mammals. Epigenetic regulatory mechanisms play a crucial role in development and regeneration. This investigation attempted to reveal the role of epigenetic regulatory mechanisms, such as histone H3 and H4 lysine acetylation and methylation during zebrafish caudal fin regeneration. It was intriguing...

article

1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine induced Parkinson's disease in zebrafish

Nukala Sarath Babu, Ch Lakshmi N. Murthy, Sameera Kakara, Rahul Sharma, more

PROTEOMICS > 16 > 9 > 1407 - 1420

Parkinson's disease (PD) is the most common age associated neurodegenerative disease, which has been extensively studied for its etiology and phenotype. PD has been widely studied in alternate model system such as rodents towards understanding the role of neurotoxin by inducing PD. This study is aimed to understand the biomechanism of PD in zebrafish model system induced by 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine...

article

Proteomic and gene expression analysis of zebrafish brain undergoing continuous light/dark stress

Sruthi Purushothaman, Sandeep Saxena, Vupalapathy Meghah, Mula G. Meena Lakshmi, more

Journal of Sleep Research > 24 > 4 > 458 - 465

Several organisms irrespective of their complexity in structure and function have an inbuilt circadian rhythm. Zebrafish could be used as an alternate model animal in sleep research as it exhibits similar sleep–wake dynamics as mammals and Drosophila. In this study, we have analysed the adult zebrafish brain for its differential proteome and gene expression during perturbed light/dark cycle. A total...

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OncomiRdbB: a comprehensive database of microRNAs and their targets in breast cancer

Rimpi Khurana, Vinod Kumar Verma, Abdul Rawoof, Shrish Tiwari, more

BMC Bioinformatics > 2014 > 15 > 1 > 1-12

Background Given the estimate that 30% of our genes are controlled by microRNAs, it is essential that we understand the precise relationship between microRNAs and their targets. OncomiRs are microRNAs (miRNAs) that have been frequently shown to be deregulated in cancer. However, although several oncomiRs have been identified and characterized, there is as yet no comprehensive compilation of this...

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Proteome map of the neural complex of the tunicate Ciona intestinalis, the closest living relative to vertebrates

Sandeep Saxena, Sam Dupont, Vuppalapaty Meghah, Mula G. Meena Lakshmi, more

PROTEOMICS > 13 > 5 > 860 - 865

Ciona intestinalis (the common sea squirt) is the closest living chordate relative to vertebrates with cosmopolitan presence worldwide. It has a relatively simple nervous system and development, making it a widely studied alternative model system in neuroscience and developmental biology. The use of Ciona as a model organism has increased significantly after the draft genome was published. In this...

article

Evidence for dynamic and multiple roles for huntingtin in Ciona intestinalis

Mohammed M. Idris, Michael C. Thorndyke, Euan R. Brown

Invertebrate Neuroscience > 2013 > 13 > 2 > 151-165

Although mutations in the huntingtin gene (HTT) due to poly-Q expansion cause neuropathology in humans (Huntington’s disease; HD), the normal function(s) of the gene and its protein (HTT) remain obscure. With new information from recently sequenced invertebrate genomes, the study of new animal models opens the possibility of a better understanding of HTT function and its evolution. To these ends,...

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Proteome profile of zebrafish kidney

Sandeep Saxena, Sachin K. Singh, Mula G. Meena Lakshmi, Vuppalapaty Meghah, more

Journal of Proteomics > 2011 > 74 > 12 > 2937-2947

The most imperative organ, kidney has been widely studied in zebrafish for its simplified structures and development. Understanding the proteomic component of kidney might lead to a better insight for understanding the structural and functional complexity of kidney. In this study we have analyzed the proteome profile of the zebrafish kidney based on gel based proteome mapping techniques involving...

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The relationship of ACE and CETP gene polymorphisms with cardiovascular disease in a cohort of Asian Indian patients with and those without type 2 diabetes

Mala Ganesan, Seema Bhaskar, Radha Mani, Mohammed M. Idris, more

Journal of Diabetes and Its Complications > 2011 > 25 > 5 > 303-308

Hypertension and dyslipidemia have been associated with cardiovascular disease (CVD). We investigated the association of candidate gene polymorphisms in angiotensin-converting enzyme (ACE) and cholesterol ester transfer protein (CETP) genes in a cohort of Asian Indian patients with and those without type 2 diabetes.PCR-based genotyping of insertion/deletion (I/D) polymorphism of ACE (rs4646994) and...

article

Proteome profile of zebrafish caudal fin based on one‐dimensional gel electrophoresis LCMS/MS and two‐dimensional gel electrophoresis MALDI MS/MS analysis

Sachin K. Singh, Mula G. Meena Lakshmi, Sandeep Saxena, Cherukuvada V. Brahmendra Swamy, more

Journal of Separation Science > 34 > 2 > 225 - 232

Zebrafish (Danio rerio) is the widely used vertebrate model animal for understanding the complexity of development and disease process. Zebrafish has been also extensively used in understanding the mechanism of regeneration for its extensive capability of regenerating fins and other tissues. We have analyzed the proteome profile of zebrafish caudal fin in its native state based on one‐dimensional...

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