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Long‐lasting oxidative stress exposure may lead to relatively stable epigenetic modifications of the DNA in order to activate anti‐oxidative defence mechanisms. Oxidative stress related DNA methylation may therefore be associated (causally or as a by‐product) with cancer. We measured derivatives of reactive oxygen metabolites (D‐ROM), total thiol levels (TTL) and DNA methylation with the Illumina...
Deregulation of apoptosis is a frequent alteration in early benign lesions of the colon mucosa and is thought to be a major contributor to tumor progression and cancer. Single nucleotide polymorphisms (SNPs) within apoptosis‐related genes could affect apoptotic responses and their identification might provide a basis to assess individual risk for development of early lesions. To investigate a possible...
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