Search results for: Bette J. Caan

Items from 1 to 20 out of 76 results

article

Individual‐ and neighborhood‐level socioeconomic status and risk of aggressive breast cancer subtypes in a pooled cohort of women from Kaiser Permanente Northern California

Rhonda‐Lee F. Aoki, Stephen P. Uong, Scarlett Lin Gomez, Stacey E. Alexeeff, more

Cancer > 127 > 24 > 4602 - 4612

Background Low socioeconomic status (SES) has been associated with a higher risk of aggressive breast cancer (BC) subtypes, but few studies have examined the independent effects of both neighborhood‐level socioeconomic status (nSES) and individual‐level SES measures. Methods This study included 5547 women from the Pathways and Life After Cancer Epidemiology cohorts who were diagnosed with invasive...

article

Cardiometabolic risk factors and survival after cancer in the Women's Health Initiative

Michael S. Simon, Theresa A. Hastert, Ana Barac, Hailey R. Banack, more

Cancer > 127 > 4 > 598 - 608

Background Cardiometabolic abnormalities are a leading cause of death among women, including women with cancer. Methods This study examined the association between prediagnosis cardiovascular health and total and cause‐specific mortality among 12,076 postmenopausal women who developed local‐ or regional‐stage invasive cancer in the Women's Health Initiative (WHI). Cardiovascular risk factors included...

article

Guideline‐concordant endometrial cancer treatment and survival in the Women's Health Initiative Life and Longevity After Cancer study

Ashley S. Felix, Eric M. McLaughlin, Bette J. Caan, David E. Cohn, more

International Journal of Cancer > 147 > 2 > 404 - 412

In the Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) cohort, we examined predictors of guideline‐concordant treatment among endometrial cancer (EC) survivors and associations between receipt of guideline‐concordant treatment and survival. Receipt of guideline‐concordant EC treatment was defined according to year‐specific National Comprehensive Cancer Network (NCCN) guidelines...

article

Prediagnosis social support, social integration, living status, and colorectal cancer mortality in postmenopausal women from the women's health initiative

Candyce H. Kroenke, Electra D. Paskett, Crystal W. Cené, Bette J. Caan, more

Cancer > 126 > 8 > 1766 - 1775

Background We evaluated associations between perceived social support, social integration, living alone, and colorectal cancer (CRC) outcomes in postmenopausal women. Methods The study included 1431 women from the Women's Health Initiative who were diagnosed from 1993 through 2017 with stage I through IV CRC and who responded to the Medical Outcomes Study Social Support survey before their CRC...

article

Meta‐analysis of 16 studies of the association of alcohol with colorectal cancer

Sarah McNabb, Tabitha A. Harrison, Demetrius Albanes, Sonja I. Berndt, more

International Journal of Cancer > 146 > 3 > 861 - 873

Alcohol consumption is an established risk factor for colorectal cancer (CRC). However, while studies have consistently reported elevated risk of CRC among heavy drinkers, associations at moderate levels of alcohol consumption are less clear. We conducted a combined analysis of 16 studies of CRC to examine the shape of the alcohol–CRC association, investigate potential effect modifiers of the association,...

article

DNA repair and cancer in colon and rectum: Novel players in genetic susceptibility

Barbara Pardini, Alda Corrado, Elisa Paolicchi, Giovanni Cugliari, more

International Journal of Cancer > 146 > 2 > 363 - 372

Interindividual differences in DNA repair systems may play a role in modulating the individual risk of developing colorectal cancer. To better ascertain the role of DNA repair gene polymorphisms on colon and rectal cancer risk individually, we evaluated 15,419 single nucleotide polymorphisms (SNPs) within 185 DNA repair genes using GWAS data from the Colon Cancer Family Registry (CCFR) and the Genetics...

article

Correction to: Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer

Stephanie A. Bien, Yu-Ru Su, David V. Conti, Tabitha A. Harrison, more

Human Genetics > 2019 > 138 > 7 > 789-791

Every author has erroneously been assigned to the affiliation “62”. The affiliation 62 belongs to the author Graham Casey.

article

Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer

Stephanie A. Bien, Yu-Ru Su, David V. Conti, Tabitha A. Harrison, more

Human Genetics > 2019 > 138 > 4 > 307-326

Genome-wide association studies have reported 56 independently associated colorectal cancer (CRC) risk variants, most of which are non-coding and believed to exert their effects by modulating gene expression. The computational method PrediXcan uses cis-regulatory variant predictors to impute expression and perform gene-level association tests in GWAS without directly measured transcriptomes. In this...

article

Differences in molecular features of triple‐negative breast cancers based on the age at diagnosis

H. Evin Gulbahce, Philip S. Bernard, Erin K. Weltzien, Rachel E. Factor, more

Cancer > 124 > 24 > 4676 - 4684

Background Although the proportion of triple‐negative breast cancers (TNBCs) diagnosed among older women is low, the number of TNBC cases is substantial because of the high incidence of breast cancer after the age of 65 years. The molecular features of TNBC in this age group have not been well described. Methods This study examined a population‐based cohort of women with stage I to III TNBC diagnosed...

article

Non-alcoholic fatty liver disease and colorectal cancer survival

Kana Wu, Mike Z. Zhai, Erin K. Weltzien, Elizabeth M. Cespedes Feliciano, more

Cancer Causes & Control > 2019 > 30 > 2 > 165-168

Purpose Liver diseases including non-alcoholic fatty liver disease (NAFLD) and ensuing alterations to the micro-environment may affect development of liver metastasis. Mirroring the rise in obesity rates, prevalence of NAFLD is increasing globally. Our objective was to examine the association between NAFLD and mortality in colorectal cancer patients. Methods Colorectal Cancer-Sarcopenia and Near-term...

article

Muscle radiodensity and mortality in patients with colorectal cancer

Candyce H. Kroenke, Carla M. Prado, Jeffrey A. Meyerhardt, Erin K. Weltzien, more

Cancer > 124 > 14 > 3008 - 3015

BACKGROUND Low skeletal muscle radiodensity (SMD) is related to higher mortality in several cancers, but the association with colorectal cancer (CRC) prognosis is unclear. METHODS This observational study included 3262 men and women from the Kaiser Permanente Northern California population diagnosed between 2006 and 2011 with AJCC stages I to III CRC. The authors evaluated hazard ratios (HRs) of...

article

Muscle mass at the time of diagnosis of nonmetastatic colon cancer and early discontinuation of chemotherapy, delays, and dose reductions on adjuvant FOLFOX: The C‐SCANS study

Elizabeth M. Cespedes Feliciano, Valerie S. Lee, Carla M. Prado, Jeffrey A. Meyerhardt, more

Cancer > 123 > 24 > 4868 - 4877

BACKGROUND For many chemotherapy regimens dosed based on body surface area (BSA), patients experience dose reductions or delays or discontinue treatment, thereby reducing survival. Consideration of body composition may be useful in individualizing chemotherapy dosing, but to the authors' knowledge few studies to date have examined the association of body composition with chemotherapy tolerance in...

article

Methodological considerations for disentangling a risk factor's influence on disease incidence versus postdiagnosis survival: The example of obesity and breast and colorectal cancer mortality in the Women's Health Initiative

Elizabeth M. Cespedes Feliciano, Ross L. Prentice, Aaron K. Aragaki, Marian L. Neuhouser, more

International Journal of Cancer > 141 > 11 > 2281 - 2290

Often, studies modeling an exposure's influence on time to disease‐specific death from study enrollment are incorrectly interpreted as if based on time to death from disease diagnosis. We studied 151,996 postmenopausal women without breast or colorectal cancer in the Women's Health Initiative with weight and height measured at enrollment (1993–1998). Using Cox regression models, we contrast hazard...

article

Body mass index, PAM50 subtype, recurrence, and survival among patients with nonmetastatic breast cancer

Elizabeth M. Cespedes Feliciano, Marilyn L. Kwan, Lawrence H. Kushi, Wendy Y. Chen, more

Cancer > 123 > 13 > 2535 - 2542

BACKGROUND Studies of obesity and survival among patients with breast cancer produce conflicting results, possibly because of heterogeneity by molecular subtype. METHODS This study examined whether the association of body mass index (BMI) at diagnosis with breast cancer recurrence and survival varied across subtypes defined by PAM50 (Prediction Analysis of Microarray 50) gene expression. Included...

article

Post‐diagnosis social networks, and lifestyle and treatment factors in the After Breast Cancer Pooling Project

Candyce H Kroenke, Yvonne L. Michael, Xiao‐Ou Shu, Elizabeth M. Poole, more

Psycho‐Oncology > 26 > 4 > 544 - 552

Objective Larger social networks have been associated with better breast cancer survival. To investigate potential mediators, we evaluated associations of social network size and diversity with lifestyle and treatment factors associated with prognosis. Methods We included 9331 women from the After Breast Cancer Pooling Project who provided data on social networks within approximately two years...

article

Postdiagnosis social networks and breast cancer mortality in the After Breast Cancer Pooling Project

Candyce H. Kroenke, Yvonne L. Michael, Elizabeth M. Poole, Marilyn L. Kwan, more

Cancer > 123 > 7 > 1228 - 1237

BACKGROUND Large social networks have been associated with better overall survival, though not consistently with breast cancer (BC)–specific outcomes. This study evaluated associations of postdiagnosis social networks and BC outcomes in a large cohort. METHODS Women from the After Breast Cancer Pooling Project (n = 9267) provided data on social networks within approximately 2 years of their diagnosis...

article

Adiposity, post-diagnosis weight change, and risk of cardiovascular events among early-stage breast cancer survivors

Elizabeth M. Cespedes Feliciano, Marilyn L. Kwan, Lawrence H. Kushi, Erin K. Weltzien, more

Breast Cancer Research and Treatment > 2017 > 162 > 3 > 549-557

Purpose Little research examines whether adiposity or post-diagnosis weight changes influence Cardiovascular disease (CVD) among breast cancer patients for whom effects may differ due to treatment and recovery. Methods We studied Stage I–III breast cancer survivors 18 to <80 years, without pre-existing CVD, diagnosed from 1997 to 2013 at Kaiser Permanente. Women reported weight at diagnosis...

article

Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk

Chenjie Zeng, Koichi Matsuda, Wei-Hua Jia, Jiang Chang, more

Gastroenterology > 2016 > 150 > 7 > 1633-1645

Known genetic factors explain only a small fraction of genetic variation in colorectal cancer (CRC). We conducted a genome-wide association study to identify risk loci for CRC.This discovery stage included 8027 cases and 22,577 controls of East-Asian ancestry. Promising variants were evaluated in studies including as many as 11,044 cases and 12,047 controls. Tumor-adjacent normal tissues from 188...

article

A pooled analysis of post‐diagnosis lifestyle factors in association with late estrogen‐receptor–positive breast cancer prognosis

Sarah Nechuta, Wendy Y. Chen, Hui Cai, Elizabeth M. Poole, more

International Journal of Cancer > 138 > 9 > 2088 - 2097

Lifestyle factors have been well studied in relation to breast cancer prognosis overall; however, associations of lifestyle and late outcomes (>5 years after diagnosis) have been much less studied, and no studies have focused on estrogen receptor‐positive (ER+) breast cancer survivors, who may have high risk of late recurrence and mortality. We utilized a large prospective pooling study to evaluate...

article

Validation of self-reported comorbidity status of breast cancer patients with medical records: the California Breast Cancer Survivorship Consortium (CBCSC)

Cheryl Vigen, Marilyn L. Kwan, Esther M. John, Scarlett Lin Gomez, more

Cancer Causes & Control > 2016 > 27 > 3 > 391-401

Purpose To compare information from self-report and electronic medical records for four common comorbidities (diabetes, hypertension, myocardial infarction, and other heart diseases). Methods We pooled data from two multiethnic studies (one case–control and one survivor cohort) enrolling 1,936 women diagnosed with breast cancer, who were members of Kaiser Permanente Northern California. Results...

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INFONA - science communication portal

Search results for: Bette J. Caan

Individual‐ and neighborhood‐level socioeconomic status and risk of aggressive breast cancer subtypes in a pooled cohort of women from Kaiser Permanente Northern California

Cardiometabolic risk factors and survival after cancer in the Women's Health Initiative

Guideline‐concordant endometrial cancer treatment and survival in the Women's Health Initiative Life and Longevity After Cancer study

Prediagnosis social support, social integration, living status, and colorectal cancer mortality in postmenopausal women from the women's health initiative

Meta‐analysis of 16 studies of the association of alcohol with colorectal cancer

DNA repair and cancer in colon and rectum: Novel players in genetic susceptibility

Correction to: Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer

Genetic variant predictors of gene expression provide new insight into risk of colorectal cancer

Differences in molecular features of triple‐negative breast cancers based on the age at diagnosis

Non-alcoholic fatty liver disease and colorectal cancer survival

Muscle radiodensity and mortality in patients with colorectal cancer

Muscle mass at the time of diagnosis of nonmetastatic colon cancer and early discontinuation of chemotherapy, delays, and dose reductions on adjuvant FOLFOX: The C‐SCANS study

Methodological considerations for disentangling a risk factor's influence on disease incidence versus postdiagnosis survival: The example of obesity and breast and colorectal cancer mortality in the Women's Health Initiative

Body mass index, PAM50 subtype, recurrence, and survival among patients with nonmetastatic breast cancer

Post‐diagnosis social networks, and lifestyle and treatment factors in the After Breast Cancer Pooling Project

Postdiagnosis social networks and breast cancer mortality in the After Breast Cancer Pooling Project

Adiposity, post-diagnosis weight change, and risk of cardiovascular events among early-stage breast cancer survivors

Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk

A pooled analysis of post‐diagnosis lifestyle factors in association with late estrogen‐receptor–positive breast cancer prognosis

Validation of self-reported comorbidity status of breast cancer patients with medical records: the California Breast Cancer Survivorship Consortium (CBCSC)

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