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The HIV‐1 envelope gp120/gp41 trimer mediates viral membrane fusion. After cluster of differentiation‐4 recognition, gp120 detaches from the virus, exposing gp41 which triggers fusion. During the fusion process, gp41 may not remain trimeric, which could have functional importance. Here, we probe the reversible association of full length gp41 (minus the cytoplasmic domain) in detergent micelles (with...
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