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The differentiation and activation of T cells are critically modulated by MAP kinases, which are in turn feed‐back regulated by dual‐specificity phosphatases (DUSPs) to determine the duration and magnitude of MAP kinase activation. DUSP4 (also known as MKP2) is a MAP kinase‐induced DUSP member that is dynamically expressed during thymocyte differentiation. We generated DUSP4‐deficient mice to study...