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Cluster randomized trials (CRTs) are widely used in different areas of medicine and public health. Recently, with increasing complexity of medical therapies and technological advances in monitoring multiple outcomes, many clinical trials attempt to evaluate multiple co‐primary endpoints. In this study, we present a power analysis method for CRTs with binary co‐primary endpoints. It is developed...
Functional enrichment analysis is conducted on high‐throughput data to provide functional interpretation for a list of genes or proteins that share a common property, such as being differentially expressed (DE). The hypergeometric P‐value has been widely used to investigate whether genes from pre‐defined functional terms, for example, Gene Ontology (GO), are enriched in the DE genes. The hypergeometric...
Summary We consider inference for data from a clinical trial of treatments for metastatic prostate cancer. Patients joined the trial with diverse prior treatment histories. The resulting heterogeneous patient population gives rise to challenging statistical inference problems when trying to predict time to progression on different treatment arms. Inference is further complicated by the need to include...
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