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In this study, we aimed to determine androgen receptor (AR) and SRD5A2 gene mutations in 45 patients characterised by 46,XY Disorders of Sex Differentiation (DSD) signs with normal testicular development referred to the Children's Medical Center from February 2015 to September 2017. Karyotype and sex hormone analyses were performed. Cytogenetic investigation showed that seven patients were 46,XX DSD,...
Glioblastoma multiforme (GBM) is the most common and first leading cause of death in primary human brain cancers. Following current interventions, despite continuous advancements in medicine, the median survival time of patients is unfavorable regardless of radiotherapy, chemotherapy, or surgery. This poor outcome is referred to “cancer stem cell” (CSC) concept. According to it a minority of cells...
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