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Flutamide is a steroid used to treat androgen‐dependent disorders and as antiepileptic, but it induces a number of non‐desirable side effects. This work was aimed at assaying the effect of flutamide and two novel synthetic steroids on the levels of GABA, glutamine and oxidative stress markers. Male Wistar rats (weight 180 g) received a single diazepam dose (5 mg/kg) 30 min prior to sacrifice (group...