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BACKGROUND:ARRY‐520 selectively inhibits the mitotic kinesin spindle protein (KSP), which leads to abnormal monopolar spindle formation and apoptosis.
METHODS:A phase 1 trial was conducted to establish the safety and the maximum tolerated dose (MTD) of ARRY‐520 given as a 1‐hour infusion in either a single dose or on a day 1, 3, and 5 divided‐dose schedule per cycle in patients with advanced or refractory...
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