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To evaluate the possible vascular effects of an environment carcinogen benzo(a)pyrene (BaP). The cytotoxicit of BaP and rat liver S9 (0.25 mg/mL)-activated BaP were examined by MTT assay. Thoracic aortic rings were dissected from Sprague-Dawley rats. Contraction of aortic rings was induced by 60 mmol/L KCl or 10 −6 mol/L phenylephrine (PE) in an ex-vivo perfusion system after BaP (100 μmol/L)...
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