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Mito‐Biomimetic Lipid Nanocarriers
In article number 2305316, Shiqi Wang, Wenguo Cui, Hélder A. Santos, and co‐workers show that when cytochrome C and lonidamine co‐loaded liposomes enter breast cancer cells, they release the cytochrome C out, which binds with Apaf‐1 protein and then assembles into apoptosomes. Since the binding of Cytochrome C and Apaf‐1 is prevented by high intracellular ATP levels,...
Apoptosis is the natural programmed cell death process, which is responsible for abnormal cell clearance. However, many cancer cells develop various mechanisms to escape apoptosis through interrupting apoptosome assembly, which is a key step to initiate apoptosis. This promotes tumorigenesis and drug resistance, and thus, poses a great challenge in cancer treatment. Herein, a biomimetic lipid nanocarrier...
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