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To determine the relative biological effectiveness (RBE) of protons in the rat spinal cord as a function of linear energy transfer (LET) and dose.The rat cervical spinal cord was irradiated with single or two equal fractions (split doses) of protons at four positions (LET 1.4–5.5 keV/µm) along a 6 cm spread-out Bragg peak (SOBP). From dose-response analysis, TD50- (dose at 50% effect probability)...
Background The present work summarizes the research activities on radiation-induced late effects in the rat spinal cord carried out within the “clinical research group ion beam therapy” funded by the German Research Foundation (DFG, KFO 214). Methods and materials Dose–response curves for the endpoint radiation-induced myelopathy were determined at 6 different positions (LET 16–99 keV/μm) within...
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