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Introduction In the time of increasing resistance and paucity of new drug development there is a growing need for strategies to enhance rational use of antibiotics in German and Austrian hospitals. An evidence-based guideline on recommendations for implementation of antibiotic stewardship (ABS) programmes was developed by the German Society for Infectious Diseases in association with the following...
Purpose Little information is available on antibiotic prescription management in German hospitals. The objective of this cross-sectional study was to determine the prevalence and components of antibiotic stewardship measures in German intensive care units (ICUs). Methods A questionnaire survey was sent to all ICUs participating in the German nosocomial infection surveillance system (n = 579) in...
Background We aimed to assess the relationship between national methicillin-resistant Staphylococcus aureus (MRSA) proportions and indicators for fair play in the European Football Championship, 2008. Finding We obtained methicillin resistance data for S. aureus from the European Antimicrobial Resistance Surveillance System (EARSS) project. All teams which qualified for the final tournament and...
Objective The purpose of this study was to determine the prevalence of extended-spectrum β-lactamase (ESBL) and vancomycin-resistant enterococci (VRE) colonisation among healthy infection control personnel and to determine risk factors for ESBL or VRE colonisation within this group. Methods Participants were recruited at an infection control symposium in 2011. Volunteers were asked to perform a...
Purpose To determine the incidence of patients co-colonised or co-infected with methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecium or extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae in four German tertiary care hospitals. Methods This study was conducted at four tertiary care hospitals (all with >1,000 beds) in different geographic...
Objective: The aim of this study was to evaluate the impactof reducing the length of antibiotic prophylaxis for cerebrospinalshunts on total antibiotic use and key resistantpathogens. Methods: In January 2004, the use of antibiotic prophylaxiswas reduced to a single shot dose with cefuroxime in anintensive care unit (ICU). Prior to this intervention, prophylaxiswith second-generation cephalosporins...
Objective: To ascertain the desirability of replacing closed suction systems after 72 h rather than after 24 h (manufacturer’s recommendations) because it is possible that a reduction in the frequency of manipulations might reduce the risk of exogenous nosocomial pneumonia. We investigated the presence of time-dependent differences (after 24 h and 72 h) in pathogen survival/growth in artificially...
In human medicine, increasing resistance in Escherichia coli strains causes therapeutic problems and is partly attributed to the selection pressure in veterinary medicine. The resistance proportions (RP) of E. coli isolates obtained in 2002/2003 from animals (n = 110) and from food originating from animals (n = 42) were highest for tetracyclines (57%), ampicillin (38%) and trimethoprim/sulfamethoxazole...
Objective: To report the experience gained over 4 years in working with the German SARI project (Surveillance of Antimicrobial Use and Antimicrobial Resistance in Intensive Care Units), and to compare SARI with data from the Swedish STRAMA and the US AUR surveillance system. Methods: Prospective unit and laboratory based surveillance was carried out in 40 German ICUs from 2001 through 2004...
Background: Data on antibiotic consumption and bacterial resistance are important for benchmarking, ensuring quality of antibiotic treatment and helping to understand the relationship between the use of antibiotics and the emergence of resistance. Methods: The SARI project is an ecological study that has established laboratory-based surveillance in German intensive care units (ICU). Resistance rates...
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