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C57BL/6 (B6) mice develop a syndrome of progressive lymphoproliferation and immunodeficiency, murine AIDS (MAIDS), when infected with an etiologic replication-defective virus termed BM5def. Induction of MAIDS requires the presence of CD4 + T cells and B cells. B6 mice with altered conventional B cell function and a deficit in CD5 + B cells due to the xid mutation develop disease with...
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