Search results for: Zhi-Ming Shao

Items from 1 to 20 out of 103 results

article

De‐escalation of five‐year adjuvant endocrine therapy in patients with estrogen receptor‐low positive (immunohistochemistry staining 1%‐10%) breast cancer: Propensity‐matched analysis from a prospectively maintained cohort

Yu‐Wen Cai, Zhi‐Ming Shao, Ke‐Da Yu

Cancer > 128 > 9 > 1748 - 1756

Background The standard 5 years of endocrine therapy has demonstrated additional benefits compared with short‐term (2‐3 years) treatment in patients with estrogen receptor (ER)‐positive breast cancer; however, data specific to ER‐low positive breast cancer (1%‐10% by immunohistochemistry) are limited, and it is unclear whether long‐term treatment is still necessary for this subgroup. Methods The...

article

Integrated molecular profiling of young and elderly patients with triple‐negative breast cancer indicates different biological bases and clinical management strategies

Ding Ma, Yi‐Zhou Jiang, Yi Xiao, Meng‐Dan Xie, more

Cancer > 126 > 14 > 3209 - 3218

Background Age at the time of breast cancer diagnosis not only predicts clinical outcome but also indicates distinct molecular characteristics that provide the rationale for appropriate treatment strategies. However, to the authors' knowledge, little is known regarding the molecular profile and biological basis of triple‐negative breast cancers (TNBCs) occurring in young and elderly patients. Methods...

article

Integration of whole‐genome sequencing and functional screening identifies a prognostic signature for lung metastasis in triple‐negative breast cancer

Guangdong Xie, Haiyuan Yang, Ding Ma, Yihua Sun, more

International Journal of Cancer > 145 > 10 > 2850 - 2860

Lung metastasis is one of the leading causes of death for triple‐negative breast cancer (TNBC). We sought to characterize the genetic alterations underlying TNBC lung metastases by integrating whole‐genome sequencing and functional screening. Furthermore, we aimed to develop a metastasis‐related gene signature for TNBC patients to improve risk stratification. In this prospective observational study,...

article

High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer

Ling Yao, Lei Wang, Zhi-Gang Cao, Xin Hu, more

Cancer Cell International > 2019 > 19 > 1 > 1-8

Background Enhanced glycolysis in tumors, known as the Warburg effect, provides the metabolic basis of enhanced cancer cell proliferation and metastasis. The Warburg pathway enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) is a newly identified key kinase that regulates transcriptional reprogramming and cell proliferation. Here we show the prognostic value of PFKFB4 expression...

article

Concurrent neoadjuvant chemotherapy and estrogen deprivation in patients with estrogen receptor–positive, human epidermal growth factor receptor 2–negative breast cancer (CBCSG‐036): A randomized, controlled, multicenter trial

Ke‐Da Yu, Si‐Yu Wu, Guang‐Yu Liu, Jiong Wu, more

Cancer > 125 > 13 > 2185 - 2193

Background The current randomized, controlled, multicenter clinical trial was conducted to investigate the efficacy of concurrent neoadjuvant chemotherapy (NCT) and estrogen deprivation in patients with estrogen receptor (ER)–positive, human epidermal growth factor receptor 2 (HER2)–negative breast cancer. Methods Eligible patients with AJCC stage IIB to stage IIIC, ER‐positive, HER2‐negative breast...

article

Nomogram for predicting preoperative lymph node involvement in patients with invasive micropapillary carcinoma of breast: a SEER population-based study

Fu-Gui Ye, Chen Xia, Ding Ma, Pei-Yang Lin, more

BMC Cancer > 2018 > 18 > 1 > 1-9

Background Invasive micropapillary carcinoma (IMPC) is an unusual and distinct subtype of invasive breast tumor with high propensity for regional lymph node metastases. This study was to identify risk factors accounting for IMPC of the breast and to develop a nomogram to preoperatively predict the probability of lymph node involvement. Methods A retrospective review of the clinical and pathology...

article

Racial/ethnic differences in the outcomes of patients with metastatic breast cancer: contributions of demographic, socioeconomic, tumor and metastatic characteristics

Jin-Xiao Ren, Yue Gong, Hong Ling, Xin Hu, more

Breast Cancer Research and Treatment > 2019 > 173 > 1 > 225-237

Purpose Population-based estimates of racial disparities in metastatic breast cancer are lacking. We quantified the contributions of demographic, socioeconomic, tumor, and metastatic characteristics to racial differences in metastatic breast cancer and characterized the most disproportional subgroup. Methods Patients diagnosed with metastatic breast cancer between 2010 and 2014 were identified using...

article

Predictive and prognostic value of Matrix metalloproteinase (MMP) - 9 in neoadjuvant chemotherapy for triple-negative breast cancer patients

Ruo-Xi Wang, Sheng Chen, Liang Huang, Zhi-Ming Shao

BMC Cancer > 2018 > 18 > 1 > 1-8

Background This study aimed to investigate the clinical utility of serum and histological MMP-9 detection during neoadjuvant chemotherapy (NAC) for triple-negative breast cancer (TNBC). Methods A total of 303 TNBC patients who underwent weekly paclitaxel plus carboplatin treatments followed by surgical resection were included in this study. Enzyme-linked immunosorbent assay (ELISA) was used to detect...

article

Correction to: Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer

Xin-Zhong Chang, Da-Qiang Li, Yi-Feng Hou, Jiong Wu, more

Breast Cancer Research > 2018 > 20 > 1 > 1-1

After the publication of this work [1] an error in Fig. 1c was brought to our attention: the Western blots for PRDX6 and β-actin were similar to those shown in lanes 5-6 of Fig. 4g. To verify these findings, we have repeated this experiment and the results are shown in a new Fig. 1c below. The repeated experimental results are consistent with the previously reported findings in the original study...

article

Clinicopathologic features and prognoses of different histologic types of triple-negative breast cancer: A large population-based analysis

Shen Zhao, Ding Ma, Yi Xiao, Yi-Zhou Jiang, more

European Journal of Surgical Oncology (EJSO) > 2018 > 44 > 4 > 420-428

To examine the clinicopathologic characteristics and survival outcomes of different histologic types of triple-negative breast cancer (TNBC).We used the SEER database to identify patients with TNBC diagnosed between 2010 and 2014. Our analysis focused on the seven most prevalent histologic types. Differences were compared between invasive carcinoma of no special type (NST) and the other six types...

article

MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer

San-Jian Yu, Liu Yang, Qi Hong, Xia-Ying Kuang, more

BMC Cancer > 2018 > 18 > 1 > 1-11

Background Emerging evidence suggests molecular and phenotypic association between treatment resistance and epithelial–mesenchymal transition (EMT) in cancer. Compared with the well-defined molecular events of miR-200a in EMT, the role of miR-200a in therapy resistance remains to be elucidated. Methods Breast cancer cells transfected with mimic or inhibitor for miR-200a was assayed for chemoresistance...

article

The spectrum of BRCA mutations and characteristics of BRCA‐associated breast cancers in China: Screening of 2,991 patients and 1,043 controls by next‐generation sequencing

Guan‐Tian Lang, Jin‐Xiu Shi, Xin Hu, Chen‐Hui Zhang, more

International Journal of Cancer > 141 > 1 > 129 - 142

To characterize the prevalence of BRCA mutations and characteristics of BRCA carriers in China and to update the clinical recommendations for BRCA testing, we conducted a wide screen for BRCA mutations using next‐generation sequencing (NGS). A total of 4,034 Chinese subjects were screened for germline BRCA1/2 mutations, including 2,991 breast cancer patients and 1,043 healthy individuals from the...

article

PD‐L1 expression of the residual tumor serves as a prognostic marker in local advanced breast cancer after neoadjuvant chemotherapy

Sheng Chen, Ruo‐Xi Wang, Yin Liu, Wen‐Tao Yang, more

International Journal of Cancer > 140 > 6 > 1384 - 1395

This study sought to investigate the prevalence of programmed death ligand 1 (PD‐L1) and its prognostic value in patients with residual tumors after neoadjuvant chemotherapy (NCT) for locally advanced breast cancer. A total of 309 patients considered as non‐pathological complete responders (non‐pCR) after NCT followed by mastectomy were selected. The expression of PD‐L1 and tumor‐infiltrating lymphocytes...

article

Clinical and molecular relevance of mutant-allele tumor heterogeneity in breast cancer

Ding Ma, Yi-Zhou Jiang, Xi-Yu Liu, Yi-Rong Liu, more

Breast Cancer Research and Treatment > 2017 > 162 > 1 > 39-48

Purpose Intra-tumor heterogeneity (ITH) plays a pivotal role in driving breast cancer progression and therapeutic resistance. We used a mutant-allele tumor heterogeneity (MATH) algorithm to measure ITH and explored its correlation with clinical parameters and multi-omics data. Methods We assessed 916 female breast cancer patients from The Cancer Genome Atlas. We calculated the MATH values from whole-exome...

article

Weekly paclitaxel plus carboplatin with or without trastuzumab as neoadjuvant chemotherapy for HER2-positive breast cancer: loss of HER2 amplification and its impact on response and prognosis

Ruo-Xi Wang, Sheng Chen, Xi Jin, Can-Ming Chen, more

Breast Cancer Research and Treatment > 2017 > 161 > 2 > 259-267

Purpose Neoadjuvant chemotherapy (NCT) plus anti-HER2 agents are the standard of care for locally advanced HER2-positive breast cancer. The aim of this study was to evaluate the prevalence and prognostic impact of HER2 loss in patients with HER2-positive disease treated with neoadjuvant therapy with or without trastuzumab. Methods 549 consecutive HER2-positive patients were included in this study...

article

The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis

Xia-Ying Kuang, He-Sheng Jiang, Kai Li, Yi-Zi Zheng, more

Cancer Letters > 2016 > 377 > 1 > 87-96

Metastasis is a major cause of death in patients with breast cancer. Stathmin1 (STMN1) is a phosphoprotein associated with cancer metastasis. It exhibits a complicated phosphorylation pattern in response to various extracellular signals, but its signaling mechanism is poorly understood. In this study, we report that phosphorylation of STMN1 at Ser25 and Ser38 is necessary to maintain cell migration...

article

Luteal versus follicular phase surgical oophorectomy plus tamoxifen in premenopausal women with metastatic hormone receptor-positive breast cancer

Richard R. Love, Syed Mozammel Hossain, Md. Margub Hussain, Mohammad Golam Mostafa, more

European Journal of Cancer > 2016 > 60 > C > 107-116

In premenopausal women with metastatic hormone receptor-positive breast cancer, hormonal therapy is the first-line therapy. Gonadotropin-releasing hormone analogue + tamoxifen therapies have been found to be more effective. The pattern of recurrence risk over time after primary surgery suggests that peri-operative factors impact recurrence. Secondary analyses of an adjuvant trial suggested that the...

article

Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex

Hongjie Shen, Wenqi Xu, Rui Guo, Bowen Rong, more

Cell > 2016 > 165 > 2 > 331-342

Regulation of enhancer activity is important for controlling gene expression programs. Here, we report that a biochemical complex containing a potential chromatin reader, RACK7, and the histone lysine 4 tri-methyl (H3K4me3)-specific demethylase KDM5C occupies many active enhancers, including almost all super-enhancers. Loss of RACK7 or KDM5C results in overactivation of enhancers, characterized by...

article

Comprehensive transcriptome analysis identifies novel molecular subtypes and subtype-specific RNAs of triple-negative breast cancer

Yi-Rong Liu, Yi-Zhou Jiang, Xiao-En Xu, Ke-Da Yu, more

Breast Cancer Research > 2016 > 18 > 1 > 1-10

Background Triple-negative breast cancer (TNBC) is a highly heterogeneous group of cancers, and molecular subtyping is necessary to better identify molecular-based therapies. While some classifiers have been established, no one has integrated the expression profiles of long noncoding RNAs (lncRNAs) into such subtyping criterions. Considering the emerging important role of lncRNAs in cellular processes,...

article

Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women

Ting-Yan Shi, Zhi Jiang, Rong Jiang, Sheng Yin, more

Tumor Biology > 2015 > 36 > 9 > 6919-6927

The kinesin-like factor 1 B (KIF1B) gene plays an important role in the process of apoptosis and the transformation and progression of malignant cells. Genetic variations in KIF1B may contribute to risk of epithelial ovarian cancer (EOC). In this study of 1,324 EOC patients and 1,386 cancer-free female controls, we investigated associations between two potentially functional single nucleotide polymorphisms...

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INFONA - science communication portal

Search results for: Zhi-Ming Shao

De‐escalation of five‐year adjuvant endocrine therapy in patients with estrogen receptor‐low positive (immunohistochemistry staining 1%‐10%) breast cancer: Propensity‐matched analysis from a prospectively maintained cohort

Integrated molecular profiling of young and elderly patients with triple‐negative breast cancer indicates different biological bases and clinical management strategies

Integration of whole‐genome sequencing and functional screening identifies a prognostic signature for lung metastasis in triple‐negative breast cancer

High expression of metabolic enzyme PFKFB4 is associated with poor prognosis of operable breast cancer

Concurrent neoadjuvant chemotherapy and estrogen deprivation in patients with estrogen receptor–positive, human epidermal growth factor receptor 2–negative breast cancer (CBCSG‐036): A randomized, controlled, multicenter trial

Nomogram for predicting preoperative lymph node involvement in patients with invasive micropapillary carcinoma of breast: a SEER population-based study

Racial/ethnic differences in the outcomes of patients with metastatic breast cancer: contributions of demographic, socioeconomic, tumor and metastatic characteristics

Predictive and prognostic value of Matrix metalloproteinase (MMP) - 9 in neoadjuvant chemotherapy for triple-negative breast cancer patients

Correction to: Identification of the functional role of peroxiredoxin 6 in the progression of breast cancer

Clinicopathologic features and prognoses of different histologic types of triple-negative breast cancer: A large population-based analysis

MicroRNA-200a confers chemoresistance by antagonizing TP53INP1 and YAP1 in human breast cancer

The spectrum of BRCA mutations and characteristics of BRCA‐associated breast cancers in China: Screening of 2,991 patients and 1,043 controls by next‐generation sequencing

PD‐L1 expression of the residual tumor serves as a prognostic marker in local advanced breast cancer after neoadjuvant chemotherapy

Clinical and molecular relevance of mutant-allele tumor heterogeneity in breast cancer

Weekly paclitaxel plus carboplatin with or without trastuzumab as neoadjuvant chemotherapy for HER2-positive breast cancer: loss of HER2 amplification and its impact on response and prognosis

The phosphorylation-specific association of STMN1 with GRP78 promotes breast cancer metastasis

Luteal versus follicular phase surgical oophorectomy plus tamoxifen in premenopausal women with metastatic hormone receptor-positive breast cancer

Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex

Comprehensive transcriptome analysis identifies novel molecular subtypes and subtype-specific RNAs of triple-negative breast cancer

Polymorphisms in the kinesin-like factor 1 B gene and risk of epithelial ovarian cancer in Eastern Chinese women

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