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P‐glycoprotein (P‐gp), a drug efflux pump, is known to alter the bioavailability of antiretroviral drugs at several sites, including the brain. We have previously shown that human immunodeficiency virus‐1 (HIV‐1) glycoprotein 120 (gp120) induces proinflammatory cytokine secretion and decreases P‐gp functional expression in rat astrocytes, a cellular reservoir of HIV‐1. However, whether P‐gp is regulated...
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