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ScopeAndrogen receptor (AR) signaling is critical for all aspects of prostate growth and tumorigenesis. The glucosinolate‐derived phenethyl isothiocyanate (PEITC) has recently been demonstrated to reduce the risk of prostate cancer (PCa) and inhibit PCa cell growth. We previously reported that p300/CBP‐associated factor (PCAF), a co‐regulator for AR, is upregulated in PCa cells through suppression...
BACKGROUNDAberrant expressions of microRNAs, including upregulation of miR‐141, are closely associated with the tumorigenesis of prostate cancer (PCa). The orphan receptor small heterodimer partner (Shp) is a co‐repressor to androgen receptor (AR) and represses AR‐regulated transcriptional activity.
METHODSHere, we investigated the correlation of Shp expression with the cellular level of miR‐141...
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