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A series of chalcones and aurones were synthesized and evaluated in vitro as monoamine oxidase inhibitors (MAOi). Our results show that aurones, which had not been previously reported as MAOi, are MAO‐B inhibitors. Thus, both families inhibited selectively the B isoform of MAO in the micromolar range, offering novel scaffolds for the design of new and potent MAO inhibitors. The main structural requirements...
The preparation and solvatochromism of anions derived from the 2,4-dinitrophenylhydrazones of 1,3-diphenylpropenone, 1-phenyl-3-(4-nitrophenyl)propenone and 1-phenyl-3-(2-thienyl)propenone are described and their behaviour was interpreted in terms of theoretical calculations of their internal charge-transfer transitions.
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