Search results for: Sihan Wu

Items from 1 to 11 out of 11 results

article

Harnessing Smectic Ordering for Electric‐Field‐Driven Guided‐Growth of Surface Topography in a Liquid Crystal Polymer

Pengrong Lyu, Jian Feng, Yishu Zeng, Yang Zhang, more

Small > 20 > 22 > n/a - n/a

The guided‐growth strategy has been widely explored and proved its efficacy in fabricating surface micro/nanostructures in a variety of systems. However, soft materials like polymers are much less investigated partly due to the lack of strong internal driving mechanisms. Herein, the possibility of utilizing liquid crystal (LC) ordering of smectic liquid crystal polymers (LCPs) to induce guided growth...

article

An Ultrathin Composite Polymer Electrolyte Dual‐Reinforced by a Polymer of Intrinsic Microporosity (PIM‐1) and Poly(tetrafluoroethylene) (PTFE) Porous Membrane

Qian Liang, Xuezhi Liu, Junyan Tang, Xiao Yan, more

Small > 20 > 22 > n/a - n/a

The performances of solid‐state polymer electrolytes are urgently required to be further improved for high energy density lithium metal batteries. Herein, a highly reinforced ultrathin composite polymer electrolyte (PLPP) is successfully fabricated in a large scale by densely filling the well‐dispersed mixture of polyethylene oxide (PEO), Li‐salt (LiTFSI) and a polymer of intrinsic microporosity (PIM‐1)...

article

CD8⁺ T cells reduce neuroretina inflammation in mouse by regulating autoreactive Th1 and Th17 cells through IFN‐γ

Sihan Wu, Xuan Zhang, Cuiping Hu, Yajie Zhong, more

European Journal of Immunology > 53 > 12 > n/a - n/a

Various regulatory CD8⁺ T‐cell subsets have been proposed for immune tolerance and have been implicated in controlling autoimmune diseases. However, their phenotypic identities and suppression mechanisms are not yet understood. This study found that coculture of T‐cell receptor (TCR)‐ or interferon (IFN)‐β‐activated CD8⁺ T cells significantly suppressed the cytokine production of Th1 and Th17 cells...

article

Targeting cancer's metabolic co-dependencies: A landscape shaped by genotype and tissue context

Junfeng Bi, Sihan Wu, Wenjing Zhang, Paul S. Mischel

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer > 2018 > 1870 > 1 > 76-87

Tumors cells reprogram their metabolism to fuel rapid growth. The ability to trace nutrient fluxes in the context of specific alterations has provided new mechanistic insight into the process of oncogenic transformation. A broad array of complementary genetic, epigenetic, transcriptional and translational mechanisms has been identified, revealing a metabolic landscape of cancer. However, cancer metabolism...

article

The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes

Fan Xing, Yizhao Luan, Jing Cai, Sihan Wu, more

Cell Reports > 2018 > 23 > 9 > 2832-2833

article

Spurious heat conduction behavior of finite-size graphene nanoribbon under extreme uniaxial strain caused by the AIREBO potential

Xueming Yang, Sihan Wu, Jiangxin Xu, Bingyang Cao, more

Physica E: Low-dimensional Systems and Nanostructures > 2018 > 96 > C > 46-53

Although the AIREBO potential can well describe the mechanical and thermal transport of the carbon nanostructures under normal conditions, previous studies have shown that it may overestimate the simulated mechanical properties of carbon nanostructures in extreme strains near fracture. It is still unknown whether such overestimation would also appear in the thermal transport of nanostructrues. In...

article

The Anti-Warburg Effect Elicited by the cAMP-PGC1α Pathway Drives Differentiation of Glioblastoma Cells into Astrocytes

Fan Xing, Yizhao Luan, Jing Cai, Sihan Wu, more

Cell Reports > 2017 > 18 > 2 > 468-481

Glioblastoma multiforme (GBM) is among the most aggressive of human cancers. Although differentiation therapy has been proposed as a potential approach to treat GBM, the mechanisms of induced differentiation remain poorly defined. Here, we established an induced differentiation model of GBM using cAMP activators that specifically directed GBM differentiation into astroglia. Transcriptomic and proteomic...

chapter

Model Checking of IoT System in Microgrid

Lulu Liang, Kai Zheng, Zilong Wei, Yanmei Wang, more

2016 8th International Conference on Information Technology in Medicine and Education (ITME) > 601 - 605

2016 8th International Conference on Information Technology in Medicine and Education (ITME)

Due to the serious air pollution, the renewable energy sources had attracted more and more attention. In order to manage the renewable energy sources, the concept of microgrid is introduced. The IoT system can also be used in microgrid for the monitoring and control. However, how to verify the reliability of the system is still a problem. In this paper, the probabilistic model checking is used to...

chapter

Model Checking PV Energy System with Remote Reprogramming Function

Sihan Wu, Kai Zheng, Xin Huang

2016 8th International Conference on Information Technology in Medicine and Education (ITME) > 606 - 610

2016 8th International Conference on Information Technology in Medicine and Education (ITME)

With the energy problems becoming serious, photovoltaic (PV) energy system attracts more and more attention. With the need of flexible control, the reliability of performance of the systems becomes more significant. In this paper, two models of the system with reprogramming function have been proposed. However, how to verify the reliability of the designed systems is a challenge. Thus this paper presents...

article

Triptolide inhibits proliferation and invasion of malignant glioma cells

Haipeng Zhang, Wenbo Zhu, Xingwen Su, Sihan Wu, more

Journal of Neuro-Oncology > 2012 > 109 > 1 > 53-62

Malignant glioma is the most devastating and aggressive tumor in brain, characterized by rapid proliferation and diffuse invasion. Chemotherapy and radiotherapy are the pivotal strategies after surgery; however, high drug resistance of malignant glioma and the blood–brain barrier usually render chemotherapy drugs ineffective. Here, we find that triptolide, a small molecule with high lipid solubility,...

article

Activation of a pro-survival pathway IL-6/JAK2/STAT3 contributes to glial fibrillary acidic protein induction during the cholera toxin-induced differentiation of C6 malignant glioma cells

Minfeng Shu, Yuxi Zhou, Wenbo Zhu, Sihan Wu, more

Molecular Oncology > 2011 > 5 > 3 > 265-272

Differentiation-inducing therapy has been proposed to be a novel potential approach to treat malignant gliomas. Glial fibrillary acidic protein (GFAP) is a well-known specific astrocyte biomarker and acts as a tumor suppressor gene (TSG) in glioma pathogenesis. Previously we reported that a traditional biotoxin cholera toxin could induce malignant glioma cell differentiation characterized by morphologic...

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