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Background
Effective inhibition of plasma kallikrein may have significant benefits for patients with hereditary angioedema due to deficiency of C1 inhibitor (C1‐INH‐HAE) by reducing the frequency of angioedema attacks. Avoralstat is a small molecule inhibitor of plasma kallikrein. This study (OPuS‐2) evaluated the efficacy and safety of prophylactic avoralstat 300 or 500 mg compared with placebo...
Background
Avoralstat is a potent small‐molecule oral plasma kallikrein inhibitor under development for treatment of hereditary angioedema (HAE). This first‐in‐human study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of avoralstat.
Methods
This double‐blind, placebo‐controlled, ascending‐dose cohort trial evaluated avoralstat single doses of 50, 125, 250, 500, and...
Transforming growth factor‐beta 1 (TGF‐β1) has been reported being involved in the remodeling and immunosuppression processes of inflammatory airway diseases; understanding the regulation of TGF‐β1 is therefore a key to unravel the pathomechanisms of these diseases. This review briefly summarizes the current knowledge on the influencing factors for driving TGF‐β1 and its regulatory pathways in inflammatory...
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