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In humans, cyclosporin A (CyA) is primarily metabolized to two hydroxylated (AM1 and AM9) and one N-demethylated (AM4N) derivative. To produce these derivatives, 1237 actinomycetes were screened for their ability to convert CyA. Among them, 89 strains (7.2%) produced these derivatives from CyA. Finally, Dactylosporangium variesporum IFO 14104, Actinoplanes sp. ATCC 53771 and Streptosporangium sp....
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