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Pannexin 1 (Panx1) is involved in endothelium-dependent vasodilation in large arteries, but the exact mechanistic role remains poorly understood. We hypothesized that Panx1 facilitates large vessel relaxations regulating endothelium-derived hyperpolarization (EDH)-like mechanisms. The EDH-like component of acetylcholine-induced relaxation of saphenous arteries studied in isometric myograph after inhibition...
The aim of this study was to reveal the changes of short-term cardiovascular variability in rats with sustained primary hypertension and correlate them with functional alterations of peripheral arteries. 12-month-old SHR as compared to Wistar rats demonstrated prominent reductions of mean arterial pressure and pulse interval spectral powers in the range 0.25–0.75 Hz. These alterations were associated...
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