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Human trisomy 21, the chromosomal basis of Down syndrome (DS), is the most common genetic cause of heart defects. Regions on human chromosome 21 (Hsa21) are syntenically conserved with three regions located on mouse chromosome 10 (Mmu10), Mmu16 and Mmu17. In this study, we have analyzed the impact of duplications of each syntenic region on cardiovascular development in mice and have found that only...
We present a new framework and method for solving Multiple Instance Learning (MIL) problems. As a variation on supervised learning, MIL addresses the problem of classifying a bag of instances. If at least one of the instances in a bag is positive the bag is labeled positive, otherwise it is negative. We use a divide and conquer strategy to identify true positive group of instances in the positive...
The pre-mRNA encoding the serotonin 2C receptor, HTR2C (official mouse gene symbol, Htr2c), is subject to adenosine deamination that produces inosine at five sites within the coding region. Combinations of this site-specific A-to-I editing can produce 32 different mRNA sequences encoding 24 different protein isoforms with differing biochemical and pharmacological properties. Studies in humans have...
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