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We present binding properties of biomolecules and their dependence on ionic strength and temperature using a microfluidic aptameric graphene field-effect transistor (FET) nanosensor. Aptamer-immobilized graphene is used to recognize target molecules, and the resulting changes in graphene conductance is measured to study the binding kinetics of biomolecules. Binding properties of aptamer-protein interactions...
We present a new approach for real-time, specific and sensitive detection of insulin using a graphene aptameric nanosensor. The nanosensor is configured as a graphene field effect transistor, where the graphene conducting channel was functionalized with a guanine-rich aptamer IGA3 that would form an anti-parallel G-quadruplex upon insulin binding. The aptamer conformational changes altered the electrical...
This paper presents an aptameric graphene nanosensor for detection of small-molecule biomarkers. To address difficulties in direct detection of small molecules associated with their low molecular weight and electrical charge, we incorporate an aptamer-based competitive affinity assay in a graphene field effect transistor (FET), and demonstrate the utility of the nanosensor with dehydroepiandrosterone...
We here present a microfluidic aptasensor that integrates aptamer-based selective analyte enrichment, isocratic elution and conductance-based graphene nanosensing, achieving sensitive and label-free detection of small biomolecules. An aptamer specific to a target analyte is immobilized on microbeads for selective enrichment and isocratic elution of the analyte. A conductance-based graphene nanosensor...
This paper presents a graphene field effect transistor (GFET) nanosensor that, with a solid gate provided by a high-κ dielectric, allows analyte detection in liquid media at low gate voltages. The gate is embedded within the sensor and thus is isolated from a sample solution, offering a high level of integration and miniaturization and eliminating errors caused by the liquid disturbance, desirable...
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