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Aims/hypothesis The genetic engineering of pancreatic beta cells could be a powerful tool for examining the role of key genes in the cause and treatment of diabetes. Here we performed a comparative study of the ability of single-stranded (ss) adeno-associated viral vectors (AAV) of serotypes 6, 8 and 9 to transduce the pancreas in vivo. Methods AAV6, AAV8 and AAV9 vectors encoding marker genes were...
AbstractAims/hypothesis. To study the role of the human 2A-adrenoceptor in the regulation of insulin secretion and the maintenance of glucose homeostasis in transgenic mice overexpressing this receptor in pancreatic beta cells.Methods. A human insulin promoter/human 2C10-adrenoceptor chimeric gene was microinjected into mouse embryos and transgenic mice were obtained.Results. Analysis by RT-PCR showed...
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