The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
FTX-3.3 is the proposed structure of a calcium-channel blocking toxin that has been isolated from the funnel web spider (Agelenopsis aperta). The effects of FTX-3.3 and one of its analogues, sFTX-3.3, on acetylcholine release, on presynaptic currents at mouse motor nerve terminals and on whole-cell sodium currents in SK.N.SH cells (a human neuroblastoma cell line) have been studied. FTX-3.3 (10-30...
Polyamines, such as the naturally occurring tetra-amine spermine, are known to exhibit anti-tumour activity through general depletion of polyamine pools, by down-regulation of key enzymes (Bernacki et al. 1992), or by DNA binding and the resulting interference with transcription. At physiological pH, the amine functional groups in spermine are all protonated. These four positive charges are able...
Recently, we reported our studies with compounds containing anthracene or acridine covalently linked, at position-9, through an amide bond to spermine affording conjugates with bifunctional modes of DNA binding (Adlam et al. 1994; Rodger et al. 1994; Carrington et al. 1996). These compounds were cytotoxic against B16 murine melanoma cells. We now report novel acridine conjugates which were synthesised...
Synthetic funnel web spider toxin (sFTX-3.3) is a polyamine amide analogue of FTX, a toxin fraction isolated from the venom of the funnel web spider, Agelenopsis aperta, that blocks P-type Ca 2+ channels. The structures of these polyamine containing compounds are not identical: sFTX-3.3 contains an amide carbonyl oxygen that is absent from the predicted structure of native FTX. Recently,...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.