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Galectin-9 (Gal-9) ameliorates autoimmune reactions by suppressing Th17 cells while augmenting Foxp3 + regulatory T cells (Tregs). However, the exact mechanism of Gal-9-mediated immune modulation has been elusive. In a MOG-induced experimental allergic encephalomyelitis model using Gal-9 −/− mice, we observed exacerbated inflammation and an increase in IL-17-producing Th17 cells balanced...
Galectin-9 up-regulated FcγRIIb expression of mouse peritoneal macrophages in vitro but down-regulated FcγRIII expression. Galectin-9-treated macrophages stimulated with immune complexes (IC) produced less TNFα and IL-1β but more IL-10 than PBS-treated macrophages. Macrophage enhancing effects on IC-induced C5a and neutrophil chemotactic activity were also diminished for galectin-9-treated macrophages...
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