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Emerging data provide initial support for the concept that a single, minimally invasive liquid biopsy test, performed in conjunction with confirmatory radiologic or other diagnostic testing, when indicated, could be deployed on a broad scale to screen individuals for multiple types of cancer. Ideally, such a test could do this in a way that yields a clinically important percentage of true‐positive...
Lay Summary
Cancer has substantial economic impacts for patients, their families and/or caregivers, employers, and the health care system. However, there is only limited understanding of how economic issues can affect access to cancer care services and the receipt of high‐quality cancer care.
Health economics research in cancer is particularly timely due to the large and increasing number of...
Patient‐reported outcomes (PROs) measure quality of life, symptoms, patient functioning, and patient perceptions of care; they are essential for gaining a full understanding of cancer care and the impact of cancer on people's lives. Repeatedly captured facility‐level and/or population‐level PROs (PRO surveillance) could play an important role in quality monitoring and improvement, benchmarking, advocacy,...
BACKGROUNDStereotactic body radiation therapy (SBRT) has demonstrated high rates of local control with low morbidity and has now emerged as the standard of care for medically inoperable, early stage non–small cell lung cancer (NSCLC). However, the impact of lung SBRT on survival in the elderly population is less clear given competing comorbid conditions. An analysis of the National Cancer Data Base...
BACKGROUNDAlthough the combination of rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R‐CHOP) is considered standard therapy for diffuse large B‐cell lymphoma (DLBCL), patterns of use and the impact of R‐CHOP on survival in patients aged >80 years are less clear.
METHODSThe Surveillance, Epidemiology, and End Results (SEER)‐Medicare database was used to characterize presentation,...
BACKGROUNDThe purpose of this study was to examine local definitive therapy for nonmetastatic breast cancer with the Patterns of Care Breast and Prostate Cancer (POCBP) study of the National Program of Cancer Registries (Centers for Disease Control and Prevention).
METHODSPOCBP medical record data were re‐abstracted in 7 state/regional registry systems (Georgia, North Carolina, Kentucky, Louisiana,...
BACKGROUNDPancreatic adenocarcinoma (PAC) has low overall survival (OS) rates and high recurrence rates following surgical resection. The role for preoperative radiation therapy (prRT) for PAC versus postoperative RT (poRT) remains uncertain. The authors used the National Cancer Data Base (NCDB) to report prRT outcomes for the largest multi‐institutional patient cohort to date.
METHODSNCDB data were...
BACKGROUNDProstate cancer treatment choices have been shown to vary by physician and patient characteristics. For patients with low‐risk, clinically localized prostate cancer, the authors examined the impact of their clinical, sociodemographic, and radiation oncologists' (RO) characteristics on the likelihood that the patients would receive combined external beam radiotherapy and brachytherapy, a...
BACKGROUNDAdjuvant radiotherapy (A‐RT) for patients with resected pancreatic adenocarcinoma (PAC) is controversial. In the current study, the authors aim to determine whether there is an association between overall survival (OS) and A‐RT dose.
METHODSNational Cancer Data Base (NCDB) data were obtained for all patients who received A‐RT for resected PAC from 1998 through 2002. Univariate and multivariate...
BACKGROUND:Diffuse large B‐cell lymphoma (DLBCL) is often cured with standard chemoimmunotherapy, but there is great heterogeneity in presentation and outcomes.
METHODS:By using Surveillance, Epidemiology, and End Results (SEER) data from 13 registries across the United States, the authors examined differences in incidence and survival for DLBCL by race. International Classification of Diseases for...
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